Validation of an semi-automated multi component method using protein precipitation LC-MS-MS for the analysis of whole blood samples
- Authors:
- Abstract:
- BACKGROUND: Solid phase extraction (SPE) are one of many multi-component methods, but can be very time-consuming and labour-intensive. Protein precipitation is, on the other hand, a much simpler and faster sample pre-treatment than SPE, and protein precipitation also has the ability to cover a wider range of components. AIM: The aim was to develop a robust semi-automated analytical method for whole blood samples based on a protein precipitation method already used in the lab (Sørensen and Hasselstrøm, 2013). The setup should improve the speed, robustness, and reliability of anteand post-mortem whole blood sample preparation for toxicological analysis; from the primary sample tube to a 96-deepwell plate ready for injection on the liquid chromatography mass spectrometry (LC-MS/MS).
- Type:
- Conference poster
- Language:
- Danish
- Keywords:
- Automation
- Main Research Area:
- Medical science
- Review type:
- Undetermined
- Conference:
- 2017 Joint meeting of the Society og Forensic Toxicologists and The International Association of Forensic Toxicologists, 2017
- Submission year:
- 2017
- Scientific Level:
- Scientific
- ID:
- 2396085126
