- Authors:
-
- Togsverd-Bo, Katrine ;
- Idorn, Luise W ;
-
Philipsen, Peter A
;
Close
0000-0002-9656-733X
Dermatology, Department of, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark - Wulf, Hans Christian ;
- Hædersdal, Merete
- Subtitle:
- methyl- and hexylaminolevulinate and different light sources
- DOI:
- 10.1111/j.1600-0625.2012.01557.x
- Abstract:
- Topical photodynamic therapy (PDT) is used for various skin disorders, and selective targeting of specific skin structures is desirable. The objective was to assess accumulation of PpIX fluorescence and photobleaching within skin layers using different photosensitizers and light sources. Normal human skin was tape-stripped and incubated with 20% methylaminolevulinate (MAL) or 20% hexylaminolevulinate (HAL) for 3 h. Fluorescence microscopy quantified PpIX accumulation in epidermis, superficial, mid and deep dermis, down to 2 mm. PpIX photobleaching by light-emitting diode (LED, 632 nm, 18 and 37 J/cm(2)), intense pulsed light (IPL, 500-650 nm, 36 and 72 J/cm(2)) and long-pulsed dye laser (LPDL, 595 nm, 7.5 and 15 J/cm(2)) was measured using fluorescence photography and microscopy. We found higher PpIX fluorescence intensities in epidermis and superficial dermis in HAL-incubated skin than MAL-incubated skin (P
- Type:
- Journal article
- Language:
- English
- Published in:
- Experimental Dermatology, 2012, Vol 21, Issue 10, p. 745-750
- Keywords:
- Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
- Main Research Area:
- Medical science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2012
- Scientific Level:
- Scientific
- ID:
- 231601999
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