Neonatal levels of cytokines and risk of autism spectrum disorders: An exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank

Morsi Abdallah; Nanna Larsen; Erik Lykke Mortensen; Hjördis Ó Atladóttir; Bent Nørgaard-Pedersen; Eva Cecilie Bonefeld-Jørgensen; Jakob Grove; David M Hougaard

doi:10.1016/j.jneuroim.2012.07.013

Neonatal levels of cytokines and risk of autism spectrum disorders

Authors:

Abdallah, Morsi ;
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Department of Public Health - Department of Epidemiology, Department of Public Health, Health, Aarhus University
Larsen, Nanna ;
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unknown
Mortensen, Erik Lykke ;
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Institut for Folkesundhedsvidenskab
Atladóttir, Hjördis Ó ;
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Department of Public Health - Department of Epidemiology, Department of Public Health, Health, Aarhus University
Nørgaard-Pedersen, Bent ;
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unknown
Bonefeld-Jørgensen, Eva Cecilie ;
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Department of Public Health - Centre for Arctic Health, Department of Public Health, Health, Aarhus University
Grove, Jakob ;
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0000-0003-2284-5744
Bioinformatics Research Centre (BiRC), Science and Technology, Aarhus University
Hougaard, David M
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unknown

Subtitle:

An exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank

DOI:

10.1016/j.jneuroim.2012.07.013

Abstract:

The aim of the study was to analyze cytokine profiles in neonatal dried blood samples (n-DBSS) retrieved from The Danish Newborn Screening Biobank of children developing Autism Spectrum Disorders (ASD) later in life and controls. Samples of 359 ASD cases and 741 controls were analyzed using Luminex xMAP technology and clinical data were retrieved from nationwide registers. Findings showed that children developing ASD were more likely to have decreased levels of both T helper-1(Th-1)-like cytokines (i.e. IFN-γ) and Th-2like cytokines (i.e. IL-4, IL-10) which may suggest a depressed or hypoactive immune cell activity during neonatal period in ASD.

Type:

Journal article

Language:

English

Published in:

Journal of Neuroimmunology, 2012, Vol 252, Issue 1-2, p. 75-82

Main Research Area:

Medical science

Publication Status:

Published

Review type:

Peer Review

Submission year:

2012

Scientific Level:

Scientific

ID:

230274351

Neonatal levels of cytokines and risk of autism spectrum disorders

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