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Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities

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Authors:
  • Nielsen, S F ;
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    unknown
  • Kharazmi, A ;
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    unknown
  • Christensen, S B
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    Orcid logo0000-0002-5773-6874
    unknown
Abstract:
Methods for selective alkylation of chalcones in the alpha- or beta-position and for selective reduction of the alpha,beta-double bond have been developed. The antiparasitic potencies of the alpha,beta-double bond modified chalcones only differ marginally from the potencies of the parent chalcones indicating that the propenone residue only functions as a spacer between the two benzene rings, which are the true pharmacophore.
Type:
Journal article
Language:
English
Published in:
Bioorganic and Medicinal Chemistry, 1998, Vol 6, Issue 7, p. 937-45
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
1998
Scientific Level:
Scientific
ID:
2282397294
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