Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities
- Authors:
- Abstract:
- Methods for selective alkylation of chalcones in the alpha- or beta-position and for selective reduction of the alpha,beta-double bond have been developed. The antiparasitic potencies of the alpha,beta-double bond modified chalcones only differ marginally from the potencies of the parent chalcones indicating that the propenone residue only functions as a spacer between the two benzene rings, which are the true pharmacophore.
- Type:
- Journal article
- Language:
- English
- Published in:
- Bioorganic and Medicinal Chemistry, 1998, Vol 6, Issue 7, p. 937-45
- Main Research Area:
- Medical science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 1998
- Scientific Level:
- Scientific
- ID:
- 2282397294
0000-0002-5773-6874