- Authors:
-
- Valen, Eivind ;
-
Sandelin, Albin Gustav
Close
0000-0002-7109-7378
Computational and RNA Biology, Department of Biology, Faculty of Science, Københavns Universitet
- DOI:
- 10.1016/j.tig.2011.08.001
- Abstract:
- A central question in cellular biology is how the cell regulates transcription and discerns when and where to initiate it. Locating transcription start sites (TSSs), the signals that specify them, and ultimately elucidating the mechanisms of regulated initiation has therefore been a recurrent theme. In recent years substantial progress has been made towards this goal, spurred by the possibility of applying genome-wide, sequencing-based analysis. We now have a large collection of high-resolution datasets identifying locations of TSSs, protein-DNA interactions, and chromatin features over whole genomes; the field is now faced with the daunting challenge of translating these descriptive maps into quantitative and predictive models describing the underlying biology. We review here the genomic and chromatin features that underlie TSS selection and usage, focusing on the differences between the major classes of core promoters.
- Type:
- Journal article
- Language:
- English
- Published in:
- Trends in Genetics, 2011, Vol 27, Issue 11, p. 475-485
- Main Research Area:
- Science/technology
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2011
- Scientific Level:
- Scientific
- ID:
- 186042912
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