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[(11)C]Mirtazapine binding in depressed antidepressant nonresponders studied by PET neuroimaging

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Authors:
  • Smith, Donald ;
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    unknown
  • Stork, Bo ;
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    unknown
  • Wegener, Gregers ;
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    Orcid logo0000-0002-0081-0068
    unknown
  • Ashkanian, Mahmoud ;
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    unknown
  • Jakobsen, Steen ;
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    Orcid logo0000-0001-5484-6237
    unknown
  • Bender, Dirk ;
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    unknown
  • Audrain, Hélène ;
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    unknown
  • Vase, Karina ;
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    unknown
  • Videbech, Poul ;
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    unknown
  • Rosenberg, Raben
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    unknown
DOI:
10.1007/s00213-009-1587-3
Abstract:
RATIONALE: Lack of benefit from antidepressant drug therapy is a major source of human suffering, affecting at least 25% of people with major depressive disorder. We want to know whether nonresponse to antidepressants can be linked to aberrant neuroreceptor binding. OBJECTIVE: This study aims to assess the antidepressant binding in brain regions of depressed nonresponders compared with healthy controls. MATERIALS AND METHODS: Healthy volunteers and depressed subjects who had failed to benefit from at least 2 antidepressant treatments were recruited by newspaper advertisements. All subjects had received no antidepressant medication for at least 2 months before positron emission tomography (PET) that was carried out with [(11)C]mirtazapine. Kinetic parameters of [(11)C]mirtazapine were determined from PET data in selected brain regions by the simplified reference tissue model. RESULTS: Binding potentials of [(11)C]mirtazapine in cerebral cortical regions were lower in depressed nonresponders than in healthy controls. Removal rates of [(11)C]mirtazapine were higher in diencephalic regions of depressed nonresponders than in healthy controls. CONCLUSIONS: PET neuroimaging with [(11)C]mirtazapine showed aberrant neuroreceptor binding in brain regions of depressed subjects who had failed to benefit from treatment with antidepressant drugs.
Type:
Journal article
Language:
English
Published in:
Psychopharmacology, 2009, Vol 206, p. 133-140
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2009
Scientific Level:
Scientific
ID:
1151315

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