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Lipid-lowering treatment to the end?

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Authors:
  • Petersen, Line Kirkeby ;
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    unknown
  • Christensen, Kaare ;
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    Orcid logo0000-0002-5429-5292
    Epidemiology, Biostatistics and Biodemography, Department of Public Health, Faculty of Health Sciences, University of Southern Denmark
  • Kragstrup, Jakob
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    Faculty of Health Sciences, University of Southern Denmark
Subtitle:
A review of observational studies and RCTs on cholesterol and mortality in 80+-year olds
DOI:
10.1093/ageing/afq129
Abstract:
People aged 80 or older are the fastest growing population in high-income countries. One of the most common causes of death among the elderly is the cardiovascular disease (CVD). Lipid-lowering treatment is common, e.g. one-third of 75-84-year-old Swedes are treated with statins. The assumption that hypercholesterolaemia is a risk factor at the highest ages seems to be based on extrapolation from younger adults. A review of observational studies shows a trend where all-cause mortality was highest when total cholesterol (TC) was lowest ('a reverse J-shaped' association between TC and all-cause mortality). Low TC (
Type:
Journal article
Language:
English
Published in:
Age and Ageing, 2010, Vol 39, Issue 6, p. 674-80
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2010
Scientific Level:
Scientific
ID:
112377825

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