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Amplification of epidermal growth factor receptor gene in renal cell carcinoma

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Authors:
  • El-Hariry, Iman ;
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    unknown
  • Powles, Thomas ;
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  • Lau, Mike R ;
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  • Sternberg, Cora N ;
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  • Ravaud, Alain ;
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  • von der Maase, Hans ;
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  • Zantl, Niko ;
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  • Harper, Peter ;
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  • Rolland, Frédéric ;
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  • Audhuy, Bruno ;
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  • Barthel, Friederike ;
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  • Machiels, Jean-Pascal ;
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  • Patel, Pina ;
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  • Kreuser, Ernst-Dietrick ;
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  • Hawkins, Robert E ;
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  • El-Hariry, Iman ;
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    unknown
  • Powles, Thomas ;
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  • Lau, Mike R ;
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    unknown
  • Sternberg, Cora N ;
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  • Ravaud, Alain ;
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  • von der Maase, Hans ;
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    unknown
  • Zantl, Niko ;
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    unknown
  • Harper, Peter Mathias ;
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  • Rolland, Frédéric ;
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  • Audhuy, Bruno ;
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  • Barthel, Friederike ;
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  • Machiels, Jean-Pascal ;
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    unknown
  • Patel, Pina ;
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  • Kreuser, Ernst-Dietrick ;
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    unknown
  • Hawkins, Robert E
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    unknown
DOI:
10.1016/j.ejca.2010.01.011
Abstract:
Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.
Type:
Journal article
Language:
English
Published in:
European Journal of Cancer, 2010, Vol 46, Issue 5, p. 859-62
Keywords:
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2010
Scientific Level:
Scientific
ID:
1123128

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