Toll-like receptors in brain development and homeostasis

Peter H Larsen; Thomas H Holm; Trevor Owens

doi:10.1126/stke.4022007pe47

Toll-like receptors in brain development and homeostasis

Authors:

Larsen, Peter H ;
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unknown
Holm, Thomas H ;
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unknown
Owens, Trevor
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0000-0001-9315-6036
unknown

DOI:

10.1126/stke.4022007pe47

Abstract:

Toll-like receptors (TLRs) are best known as initiators of the innate immune response to pathogens. Recent reports now reveal intriguing roles for TLRs in the central nervous system (CNS). These include the regulation of neuroinflammation and of neurite outgrowth. The archetypal Toll protein in Drosophila melanogaster was implicated in the development of the nervous system. Now similar functions have been uncovered for the mammalian orthologs, the TLRs. TLRs expressed on CNS glia and neurons may recognize endogenous ligands and participate both in development and in responses associated with CNS injury

Type:

Journal article

Language:

English

Published in:

Signal Transduction Knowledge Environment (stke), 2007, Vol 2007, Issue 402

Keywords:

Animals; Brain; Drosophila melanogaster; Homeostasis; Inflammation; Mice; Mice, Knockout; Toll-Like Receptors

Main Research Area:

Medical science

Publication Status:

Published

Review type:

Peer Review

Submission year:

2007

Scientific Level:

Scientific

ID:

109586661

Toll-like receptors in brain development and homeostasis

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