• EN
  • DA

Danish NationalResearch Database

  • Publications
  • Researchers
Example Finds records
water{} containing the word "water".
water supplies"{}" containing the phrase "water supplies".
author:"Doe, John"author:"{}" containing the phrase "Doe, John" in the author field.
title:IEEEtitle:{} containing the word "IEEE" in the title field.
bech{} containing the word "bech".
marie bech"{}" containing the phrase "marie bech".
orcid:0000-0002-5429-5292orcid:{} Having a particular ORCID
Need more help? Advanced search tutorial
  • Selected (0)
  • History

Acquisition and decay of antibodies to pregnancy-associated variant antigens on the surface of <em>Plasmodium falciparum</em>-infected erythrocytes that protect against placental parasitemia

    • Save to Mendeley
    • Export to BibTeX
    • Export to RIS
    • Email citation
Authors:
  • Staalsoe, T ;
    Close
    unknown
  • Megnekou, R ;
    Close
    unknown
  • Fievét, N ;
    Close
    unknown
  • Ricke, C H ;
    Close
    Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
  • Zornig, H D ;
    Close
    unknown
  • Leke, R ;
    Close
    unknown
  • Taylor, D W ;
    Close
    Natural History Museum of Denmark, Faculty of Science, Københavns Universitet
  • Deloron, P ;
    Close
    unknown
  • Hviid, L
    Close
    Orcid logo0000-0002-1698-4927
    Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, Københavns Universitet
DOI:
10.1086/322809
Abstract:
Otherwise clinically immune women in areas endemic for malaria are highly susceptible to Plasmodium falciparum malaria during their first pregnancy. Pregnancy-associated malaria (PAM) is characterized by placental accumulation of infected erythrocytes that adhere to chondroitin sulfate A (CSA). Susceptibility to PAM decreases with increasing parity, apparently due to acquisition of antibodies directed against the variant surface antigens (VSAs) that mediate the adhesion to CSA (VSA(CSA)). This study found that levels of VSA(CSA)-specific antibodies depend on endemicity, that anti-VSA(CSA) IgG is acquired during gestation week 20, and that plasma levels of the antibodies decline during the postpartum period. There is evidence that VSA(CSA)-specific antibodies are linked to placental infection and that high antibody levels contribute to the control of placental infection by inhibiting parasite adhesion to CSA. Data suggest that VSA(CSA) is a target for vaccination against PAM.
Type:
Journal article
Language:
English
Published in:
Journal of Infectious Diseases, 2001, Vol 184, Issue 5, p. 618-26
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2001
Scientific Level:
Scientific
ID:
54439193

Full text access

  • Doi Get publisher edition via DOI resolver
Checking for on-site access...

On-site access

At institution

  • Copenhagen university.en
Feedback

Sitemap

  • Search
    • Statistics
    • Tutorial
    • Data
    • FAQ
    • Contact
  • About
    • Institutions
    • Release History
    • Cookies and Personal Data
  • Open Access
    • The Danish Open Access Indicator

Copyright © 1998–2018.

Fivu en