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Parenteral lipids and partial enteral nutrition affect hepatic lipid composition but have limited short term effects on formula-induced necrotizing enterocolitis in preterm piglets

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Authors:
  • Vegge, Andreas ;
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    Novo Nordisk A/S (Biz)
  • Thymann, Thomas ;
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    Orcid logo0000-0001-7480-6064
    Department of Nutrition, Exercise and Sports, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet
  • Lauritzen, Lotte ;
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    Orcid logo0000-0001-7184-5949
    Paediatric and International Nutrition, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet
  • Bering, Stine Brandt ;
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    Orcid logo0000-0002-6125-7892
    Clinical and Experimental Nutrition, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet
  • Wiinberg, Bo ;
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    IKVH Medicin, Onkologi, og klinisk Patologi, Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
  • Sangild, Per Torp
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    Clinical and Experimental Nutrition, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet
DOI:
10.1016/j.clnu.2014.03.004
Abstract:
Rapid transition from total parenteral nutrition (TPN) to enteral feeding is a risk factor for necrotizing enterocolitis (NEC) in preterm infants. We hypothesized that partial enteral nutrition with colostrum, increased proportion of n-3 polyunsaturated fatty acids (PUFA), or exclusion of lipid in TPN would affect short term NEC sensitivity and liver function.
Type:
Journal article
Language:
English
Published in:
Clinical Nutrition, 2015, Vol 34, Issue 2, p. 219-228
Keywords:
Animal Feed; Animals; Animals, Newborn; Colostrum; Disease Models, Animal; Enteral Nutrition; Enterocolitis, Necrotizing; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fish Oils; Guinea Pigs; Lipid Metabolism; Liver; Parenteral Nutrition; Premature Birth; Treatment Outcome; Journal Article; Research Support, Non-U.S. Gov't
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2015
Scientific Level:
Scientific
ID:
266214063

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