Histologic and Immunohistochemical classification of 41 bovine adrenal gland neoplasms

Anette Blak Grossi; Páll S. Leifsson; Henrik Elvang Jensen; Ben Vainer; Tine Moesgaard Iburg

doi:10.1177/0300985812469638

Histologic and Immunohistochemical classification of 41 bovine adrenal gland neoplasms

Authors:

Grossi, Anette Blak ;
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Experimental Animal Models, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
Leifsson, Páll S. ;
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0000-0003-1539-9491
Experimental Animal Models, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
Jensen, Henrik Elvang ;
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0000-0001-7277-7829
Experimental Animal Models, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
Vainer, Ben ;
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Molecular Pathology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
Iburg, Tine Moesgaard
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Section of Pathology, Department of Veterinary Disease Biology, Faculty of Life Sciences, Københavns Universitet

DOI:

10.1177/0300985812469638

Abstract:

Tumors of the adrenal glands are among the most frequent tumors in cattle; however, few studies have been conducted to describe their characteristics. The aim of this study was to classify 41 bovine adrenal neoplasms from 40 animals based on macroscopic and histologic examination, including electron microscopy and immunohistochemistry for melan A, synaptophysin, chromogranin A, vimentin, pan-cytokeratin, 2',3'-cyclic nucleotide-3'-phosphohydrolase (CNPase), and Ki-67. The tumors were classified as 23 adrenocortical adenomas, 12 adrenocortical carcinomas, 2 schwannomas, 2 pheochromocytomas (1 malignant), and 1 ganglioneuroma. Five histologic features were characteristic of metastasizing adrenocortical tumors: invasion of the capsule, vascular invasion, diffuse growth pattern, spindle-cell morphology, and nuclear pleomorphism. Adrenocortical tumors with at least 3 of these features were classified as malignant. Immunohistochemically, adrenocortical tumors expressed melan A (16/19), vimentin (14/26), cytokeratin (11/26), and chromogranin A (9/27), whereas pheochromocytomas expressed chromogranin A (2/2), synaptophysin (2/2), and vimentin (1/2). Both schwannomas expressed CNPase. An immunohistochemistry panel consisting of antibodies against melan A, synaptophysin, and CNPase was considered most useful to classify bovine adrenal tumors. However, the distinction between benign and malignant adrenocortical tumors was based on histologic features as in human medicine.

Type:

Journal article

Language:

English

Published in:

Veterinary Pathology, 2013, Vol 50, Issue 3, p. 534-542

Keywords:

Journal Article

Main Research Area:

Medical science

Publication Status:

Published

Review type:

Peer Review

Submission year:

2012

Scientific Level:

Scientific

ID:

241213682

Histologic and Immunohistochemical classification of 41 bovine adrenal gland neoplasms

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