Intermittent preventive therapy in pregnancy and incidence of low birth weight in malaria-endemic countries
- Authors:
-
- Cates, Jordan E. ;
- Westreich, Daniel ;
- Unger, Holger W. ;
- Bauserman, Melissa ;
- Adair, Linda ;
- Cole, Stephen R. ;
- Meshnick, Steven ;
- Rogerson, Stephen J. ;
- Briand, V. ;
- Fievet, N. ;
- Valea, I. ;
- Tinto, H. ;
- D'Alessandro, U. ;
- Landis, S. H. ;
- Lartey, A. ;
- Dewey, K. G. ;
- TerKuile, F. O. ;
- Dellicour, S. ;
- Van Eijk, A. M. ;
- Desai, M. ;
- Owidhi, M. ;
- L'Ianziva, A. ;
- Aol, G. ;
- Were, V. ;
- Kariuki, S. ;
- Ayisi, J. ;
- Terlouw, D. J. ;
- Madanitsa, M. ;
- Mwapasa, V. ;
- Maleta, K. ;
- Ashorn, P. ;
- Mueller, I. ;
- Stanisic, D. ;
-
Schmiegelow, C.
;
Close
0000-0002-9360-9741
Department of Immunology and Microbiology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, Københavns Universitet - Lusingu, J. P.A.
- DOI:
- 10.2105/AJPH.2017.304251
- Abstract:
- Objectives. To estimate the impact of hypothetical antimalarial and nutritional interventions (which reduce the prevalence of low midupper arm circumference [MUAC]) on the incidence of low birth weight (LBW). Methods. We analyzed data from 14 633 pregnancies from 13 studies conducted across Africa and the Western Pacific from 1996 to 2015. We calculated population intervention effects for increasing intermittent preventive therapy in pregnancy (IPTp), full coverage with bed nets, reduction in malaria infection at delivery, and reductions in the prevalence of low MUAC. Results. We estimated that, compared with observed IPTp use, administering 3 or more doses of IPTp to all women would decrease the incidence of LBW from 9.9% to 6.9% (risk difference = 3.0%; 95% confidence interval = 1.7%, 4.0%). The intervention effects for eliminating malaria at delivery, increasing bed net ownership, and decreasing low MUAC prevalence were all modest. Conclusions. Increasing IPTp uptake to at least 3 doses could decrease the incidence of LBW in malaria-endemic countries. The impact of IPTp on LBW was greater than the effect of prevention of malaria, consistent with a nonmalarial effect of IPTp, measurement error, or selection bias.
- Type:
- Journal article
- Language:
- English
- Published in:
- American Journal of Public Health, 2018, Vol 108, Issue 3, p. 399-406
- Keywords:
- Journal Article
- Main Research Area:
- Medical science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2018
- Scientific Level:
- Scientific
- ID:
- 2395625550
