Non-selective beta-blockers and handling of esophageal varices has been key elements in the treatment of portal hypertension in recent decades. Liver vein catheterization has been essential in diagnosis and monitoring of portal hypertension, but ongoing needs for noninvasive tools has led to research in areas of both biomarkers, and transient elastography, which displays promising results in discerning clinically significant portal hypertension. Novel research into the areas of hepatic stellate cell function and the dynamic components of portal hypertension has revealed promising areas of treatment modalities, targeting intestinal decontamination, angiogenesis, inflammation and oxidative stress. Future studies may reveal if these initiatives lead to developments of new drugs for treatment of portal hypertension.
Journal review article
Expert Review of Gastroenterology and Hepatology, 2016, Vol 10, Issue 8, p. 961-9
Journal Article; Review; Animals; Diffusion of Innovation; Disease Progression; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hemostatic Techniques; Humans; Hypertension, Portal; Liver Cirrhosis; Molecular Targeted Therapy; Portal Pressure; Predictive Value of Tests; Risk Factors; Treatment Outcome