We briefly reviewed one definition of dose addition, which is applicable within the framework of generalized linear models. We established how this definition of dose addition corresponds to effect addition in case only two doses per compound are considered for evaluating synergistic effects. The link between definitions was exemplified for an appetite study where two appetite hormones were studied.
Synergy, 2016, Vol 3, Issue 1, p. 1-2
Analysis of covariance; Dose addition; Effect addition; Linear mixed model