• EN
  • DA

Danish NationalResearch Database

  • Publications
  • Researchers
Example Finds records
water{} containing the word "water".
water supplies"{}" containing the phrase "water supplies".
author:"Doe, John"author:"{}" containing the phrase "Doe, John" in the author field.
title:IEEEtitle:{} containing the word "IEEE" in the title field.
bech{} containing the word "bech".
marie bech"{}" containing the phrase "marie bech".
orcid:0000-0002-5429-5292orcid:{} Having a particular ORCID
Need more help? Advanced search tutorial
  • Selected (0)
  • History

Increased serum β2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients

    • Save to Mendeley
    • Export to BibTeX
    • Export to RIS
    • Email citation
Authors:
  • Hermansen, M-L F ;
    Close
    unknown
  • Hummelshøj, L ;
    Close
    unknown
  • Lundsgaard, Dorte ;
    Close
    unknown
  • Hornum, L ;
    Close
    unknown
  • Keller, P ;
    Close
    Infectious Diseases, Department of, Finsencentret, Rigshospitalet, The Capital Region of Denmark
  • Fleckner, Jan ;
    Close
    unknown
  • Fox, B ;
    Close
    unknown
  • Poulsen, L K ;
    Close
    Dermatology and Allergy, Herlev and Gentofte Hospital, The Capital Region of Denmark
  • Jacobsen, Søren
    Close
    Infectious Diseases, Department of, Finsencentret, Rigshospitalet, The Capital Region of Denmark
DOI:
10.1177/0961203312447668
Abstract:
The objective of this study was to explore the relationship between serum levels of β2-microglobulin (β2MG), which some studies suggest reflect disease activity in systemic lupus erythematosus (SLE), and various clinical and immunological markers of disease activity in SLE. Twenty-six SLE patients and 10 healthy controls were included. Disease activity was assessed by: SLEDAI, 24 hr-proteinuria, circulating levels of complement C3, anti-double-stranded DNA (anti-dsDNA), β2MG and various pro-inflammatory and anti-inflammatory cytokines (IL-6, IL-8, IL-10, IL-18) measured with a multiplex assay, IFN-α assessed with a reporter gene assay, and a combined expression score of 12 IFN-α inducible genes in peripheral blood mononuclear cells. Median serum levels of β2MG were significantly higher in SLE patients vs controls (2.8 mg/L, range: 1.1-21.6 and 1.2 mg/L, range: 0.9-1.7, respectively, p 
Type:
Journal article
Language:
English
Published in:
Lupus, 2012, Vol 21, Issue 10, p. 1098-104
Keywords:
Adult; Aged; Antibodies, Antinuclear; Biological Markers; Case-Control Studies; Complement C3; Cytokines; Female; Gene Expression; Humans; Interferon-alpha; Lupus Erythematosus, Systemic; Middle Aged; Young Adult; beta 2-Microglobulin; Journal Article; Research Support, Non-U.S. Gov't
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2012
Scientific Level:
Scientific
ID:
228729053

Full text access

  • Doi Get publisher edition via DOI resolver
Checking for on-site access...

On-site access

At institution

  • Capital region

Metrics

Feedback

Sitemap

  • Search
    • Statistics
    • Tutorial
    • Data
    • FAQ
    • Contact
  • About
    • Institutions
    • Release History
    • Cookies and Personal Data
  • Open Access
    • The Danish Open Access Indicator

Copyright © 1998–2018.

Fivu en