Increased serum β2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients
- Authors:
- DOI:
- 10.1177/0961203312447668
- Abstract:
- The objective of this study was to explore the relationship between serum levels of β2-microglobulin (β2MG), which some studies suggest reflect disease activity in systemic lupus erythematosus (SLE), and various clinical and immunological markers of disease activity in SLE. Twenty-six SLE patients and 10 healthy controls were included. Disease activity was assessed by: SLEDAI, 24 hr-proteinuria, circulating levels of complement C3, anti-double-stranded DNA (anti-dsDNA), β2MG and various pro-inflammatory and anti-inflammatory cytokines (IL-6, IL-8, IL-10, IL-18) measured with a multiplex assay, IFN-α assessed with a reporter gene assay, and a combined expression score of 12 IFN-α inducible genes in peripheral blood mononuclear cells. Median serum levels of β2MG were significantly higher in SLE patients vs controls (2.8 mg/L, range: 1.1-21.6 and 1.2 mg/L, range: 0.9-1.7, respectively, p
- Type:
- Journal article
- Language:
- English
- Published in:
- Lupus, 2012, Vol 21, Issue 10, p. 1098-104
- Keywords:
- Adult; Aged; Antibodies, Antinuclear; Biological Markers; Case-Control Studies; Complement C3; Cytokines; Female; Gene Expression; Humans; Interferon-alpha; Lupus Erythematosus, Systemic; Middle Aged; Young Adult; beta 2-Microglobulin; Journal Article; Research Support, Non-U.S. Gov't
- Main Research Area:
- Medical science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2012
- Scientific Level:
- Scientific
- ID:
- 228729053
