- Authors:
-
-
Eguen, Teinai Ebimienere
;
Close
0000-0001-5609-3742
Section for Plant Biochemistry, Department of Plant and Environmental Sciences, Faculty of Science, Københavns Universitet -
Straub, Daniel
;
Close0000-0002-2553-0660
Section for Plant Biochemistry, Department of Plant and Environmental Sciences, Faculty of Science, Københavns Universitet -
Graeff, Moritz
;
Close0000-0001-6316-7770
Section for Plant Biochemistry, Department of Plant and Environmental Sciences, Faculty of Science, Københavns Universitet -
Wenkel, Stephan
Close0000-0001-5764-9423
Section for Plant Biochemistry, Department of Plant and Environmental Sciences, Faculty of Science, Københavns Universitet
-
Eguen, Teinai Ebimienere
;
- Subtitle:
- small size - big impact
- DOI:
- 10.1016/j.tplants.2015.05.011
- Abstract:
- MicroProteins (miPs) are short, usually single-domain proteins that, in analogy to miRNAs, heterodimerize with their targets and exert a dominant-negative effect. Recent bioinformatic attempts to identify miPs have resulted in a list of potential miPs, many of which lack the defining characteristics of a miP. In this opinion article, we clearly state the characteristics of a miP as evidenced by known proteins that fit the definition; we explain why modulatory proteins misrepresented as miPs do not qualify as true miPs. We also discuss the evolutionary history of miPs, and how the miP concept can extend beyond transcription factors (TFs) to encompass different non-TF proteins that require dimerization for full function.
- Type:
- Journal article
- Language:
- English
- Published in:
- Trends in Plant Science, 2015, Vol 20, Issue 8
- Main Research Area:
- Science/technology
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2015
- Scientific Level:
- Scientific
- ID:
- 2279600347
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