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Genetics of complex diseases

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Authors:
  • Mellerup, Erling ;
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    Department of Neuroscience, Faculty of Health and Medical Sciences, Københavns Universitet
  • Møller, Gert Lykke ;
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    unknown
  • Koefoed, Pernille
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    Department of Neuroscience, Faculty of Health and Medical Sciences, Københavns Universitet
Subtitle:
Variations on a theme
DOI:
10.1016/j.mehy.2012.02.019
Abstract:
A complex disease with an inheritable component is polygenic, meaning that several different changes in DNA are the genetic basis for the disease. Such a disease may also be genetically heterogeneous, meaning that independent changes in DNA, i.e. various genotypes, can be the genetic basis for the disease. Each of these genotypes may be characterized by specific combinations of key genetic changes. It is suggested that even if all key changes are found in genes related to the biology of a certain disease, the number of combinations may be so large that the number of different genotypes may be close to the number of patients suffering from the disease. This hypothesis is based on a study of bipolar disorder.
Type:
Journal article
Language:
English
Published in:
Medical Hypotheses, 2012, Vol 78, Issue 6, p. 732-4
Keywords:
Journal Article; Bipolar Disorder; Brain; Cell Communication; Genetic Diseases, Inborn; Genetic Variation; Genotype; Humans; Multifactorial Inheritance; Polymorphism, Single Nucleotide
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2012
Scientific Level:
Scientific
ID:
226540565

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