- Authors:
- Subtitle:
- Variations on a theme
- DOI:
- 10.1016/j.mehy.2012.02.019
- Abstract:
- A complex disease with an inheritable component is polygenic, meaning that several different changes in DNA are the genetic basis for the disease. Such a disease may also be genetically heterogeneous, meaning that independent changes in DNA, i.e. various genotypes, can be the genetic basis for the disease. Each of these genotypes may be characterized by specific combinations of key genetic changes. It is suggested that even if all key changes are found in genes related to the biology of a certain disease, the number of combinations may be so large that the number of different genotypes may be close to the number of patients suffering from the disease. This hypothesis is based on a study of bipolar disorder.
- Type:
- Journal article
- Language:
- English
- Published in:
- Medical Hypotheses, 2012, Vol 78, Issue 6, p. 732-4
- Keywords:
- Bipolar Disorder; Brain; Cell Communication; Genetic Diseases, Inborn; Genetic Variation; Genotype; Humans; Multifactorial Inheritance; Polymorphism, Single Nucleotide; Journal Article
- Main Research Area:
- Medical science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2012
- Scientific Level:
- Scientific
- ID:
- 226540565
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