The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal

Morag H Stewart; Mareike Albert; Patrycja Sroczynska; V Adam Cruickshank; Yanping Guo; Derrick J Rossi; Kristian Helin; Tariq Enver

doi:10.1182/blood-2014-08-596734

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal

Authors:

Stewart, Morag H ;
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unknown
Albert, Mareike ;
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Helin Group, BRIC Research Groups, BRIC, Københavns Universitet
Sroczynska, Patrycja ;
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Helin Group, BRIC Research Groups, BRIC, Københavns Universitet
Cruickshank, V Adam ;
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Helin Group, BRIC Research Groups, BRIC, Københavns Universitet
Guo, Yanping ;
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unknown
Rossi, Derrick J ;
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unknown
Helin, Kristian ;
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0000-0003-1975-6097
Helin Group, BRIC Research Groups, BRIC, Københavns Universitet
Enver, Tariq
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unknown

DOI:

10.1182/blood-2014-08-596734

Abstract:

Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and differentiation in stem cells and cancer, however its function in hematopoiesis is unclear. Here, we find that Jarid1b is highly expressed in primitive hematopoietic compartments and is overexpressed in acute myeloid leukemias. Constitutive genetic deletion of Jarid1b did not impact steady-state hematopoiesis. In contrast, acute deletion of Jarid1b from bone marrow increased peripheral blood T cells and, following secondary transplantation, resulted in loss of bone marrow reconstitution. Our results reveal that deletion of Jarid1b compromises hematopoietic stem cell (HSC) self-renewal capacity and suggest that Jarid1b is a positive regulator of HSC potential.

Type:

Journal article

Language:

English

Published in:

Blood, 2015

Main Research Area:

Science/technology

Publication Status:

Published

Review type:

Peer Review

Submission year:

2015

Scientific Level:

Scientific

ID:

2264388767

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal

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