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The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal

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Authors:
  • Stewart, Morag H ;
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    unknown
  • Albert, Mareike ;
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    Helin Group, BRIC Research Groups, BRIC, Københavns Universitet
  • Sroczynska, Patrycja ;
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    Helin Group, BRIC Research Groups, BRIC, Københavns Universitet
  • Cruickshank, V Adam ;
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    Helin Group, BRIC Research Groups, BRIC, Københavns Universitet
  • Guo, Yanping ;
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    unknown
  • Rossi, Derrick J ;
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    unknown
  • Helin, Kristian ;
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    Orcid logo0000-0003-1975-6097
    Helin Group, BRIC Research Groups, BRIC, Københavns Universitet
  • Enver, Tariq
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    unknown
DOI:
10.1182/blood-2014-08-596734
Abstract:
Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and differentiation in stem cells and cancer, however its function in hematopoiesis is unclear. Here, we find that Jarid1b is highly expressed in primitive hematopoietic compartments and is overexpressed in acute myeloid leukemias. Constitutive genetic deletion of Jarid1b did not impact steady-state hematopoiesis. In contrast, acute deletion of Jarid1b from bone marrow increased peripheral blood T cells and, following secondary transplantation, resulted in loss of bone marrow reconstitution. Our results reveal that deletion of Jarid1b compromises hematopoietic stem cell (HSC) self-renewal capacity and suggest that Jarid1b is a positive regulator of HSC potential.
Type:
Journal article
Language:
English
Published in:
Blood, 2015
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2015
Scientific Level:
Scientific
ID:
2264388767

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