Cell-derived microparticles have gained a broad interest in the past years. Being released by blood cells upon activation or induction of apoptosis, they have a great potential as novel diagnostic markers and their investigation can bring new knowledge into the pathogenesis of various diseases. However, new analysis methods are required to correctly and reliably investigate these small biological particles (between 50 and 1000 nm). In this work, we aimed at developing an in vitro population of cell-derived microparticles from endothelial cells. The size of the microparticles was analysed by atomic force microscopy.
Journal of Nanomaterials and Molecular Nanotechnology, 2014, Issue S2
Cell-derived microparticles; Atomic force microscopy; Apoptosis