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Niacin and biosynthesis of PGD₂ by platelet COX-1 in mice and humans

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Authors:
  • Song, Wen-Liang ;
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    unknown
  • Stubbe, Jane ;
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    Kardiovaskulær og Renal Forskning, Department of Molecular Medicine, Faculty of Health Sciences, SDU
  • Ricciotti, Emanuela ;
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    unknown
  • Alamuddin, Naji ;
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    unknown
  • Ibrahim, Salam ;
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    unknown
  • Crichton, Irene ;
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    unknown
  • Prempeh, Maxwell ;
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    unknown
  • Lawson, John A ;
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    unknown
  • Wilensky, Robert L ;
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    unknown
  • Rasmussen, Lars Melholt ;
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    Clinical Biochemistry, Department of Clinical Research, Faculty of Health Sciences, SDU
  • Puré, Ellen ;
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    unknown
  • FitzGerald, Garret A
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    unknown
DOI:
10.1172/JCI59262
Abstract:
The clinical use of niacin to treat dyslipidemic conditions is limited by noxious side effects, most commonly facial flushing. In mice, niacin-induced flushing results from COX-1-dependent formation of PGD₂ and PGE₂ followed by COX-2-dependent production of PGE₂. Consistent with this, niacin-induced flushing in humans is attenuated when niacin is combined with an antagonist of the PGD₂ receptor DP1. NSAID-mediated suppression of COX-2-derived PGI₂ has negative cardiovascular consequences, yet little is known about the cardiovascular biology of PGD₂. Here, we show that PGD₂ biosynthesis is augmented during platelet activation in humans and, although vascular expression of DP1 is conserved between humans and mice, platelet DP1 is not present in mice. Despite this, DP1 deletion in mice augmented aneurysm formation and the hypertensive response to Ang II and accelerated atherogenesis and thrombogenesis. Furthermore, COX inhibitors in humans, as well as platelet depletion, COX-1 knockdown, and COX-2 deletion in mice, revealed that niacin evoked platelet COX-1-derived PGD₂ biosynthesis. Finally, ADP-induced spreading on fibrinogen was augmented by niacin in washed human platelets, coincident with increased thromboxane (Tx) formation. However, in platelet-rich plasma, where formation of both Tx and PGD₂ was increased, spreading was not as pronounced and was inhibited by DP1 activation. Thus, PGD₂, like PGI₂, may function as a homeostatic response to thrombogenic and hypertensive stimuli and may have particular relevance as a constraint on platelets during niacin therapy.
Type:
Journal article
Language:
English
Published in:
Journal of Clinical Investigation, 2012, Vol 122, Issue 4, p. 1459-68
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2012
Scientific Level:
Scientific
ID:
225984438

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