- Authors:
-
- Bräuner, E V ;
-
Loft, S
;
Close
0000-0001-9552-8518
Department of Public Health, Faculty of Health and Medical Sciences, Københavns Universitet - Raaschou-Nielsen, O ;
- Vogel, Ulla Birgitte ;
- Andersen, P S ;
- Sørensen, M
- DOI:
- 10.1038/gene.2011.51
- Abstract:
- The first common genetic factor identified for pediatric asthma by genome-wide association is the chromosome 17q21 locus, harbouring the ORMDL3 gene. ORMDL3 is involved in facilitation of endoplasmic reticulum-mediated inflammatory responses, believed to underlie its asthma association. We investigated associations between the rs7216389 polymorphism in the 17q21 locus affecting ORMDL3 expression and the risk for recurrent wheeze and interactions with exposure to tobacco smoke and furred pets during pregnancy and infancy using a birth cohort of 101¿042 infants. Rs7216389 was significantly associated with recurrent wheeze risk among 18-month-old infants. There was a 1.35-fold higher risk of recurrent wheeze among homozygous variant allele carriers compared with homozygous wild-type allele carriers. There was significant interaction between rs7216389 and domestic furred pets, with a positive association between pets and wheeze among homozygous wild-type carriers and a negative association among homozygous variant allele carriers. There was no interaction between rs7216389 and tobacco smoke exposure.
- Type:
- Journal article
- Language:
- English
- Published in:
- Genes and Immunity, 2012, Vol 13, Issue 1, p. 94-7
- Main Research Area:
- Medical science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2012
- Scientific Level:
- Scientific
- ID:
- 192978116
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