- Authors:
-
- Fode, Peder ;
- Jespersgaard, Cathrine ;
- Hardwick, Robert J ;
- Bogle, Helen ;
-
Theisen, Michael
;
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0000-0003-4412-1392
GLURP team, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, Københavns Universitet - Dodoo, Daniel ;
- Lenicek, Martin ;
- Vitek, Libor ;
- Vieira, Ana ;
- Freitas, Joao ;
- Andersen, Paal Skytt ;
- Hollox, Edward J
- Subtitle:
- a comparison of three methods
- DOI:
- 10.1371/journal.pone.0016768
- Abstract:
- There have been conflicting reports in the literature on association of gene copy number with disease, including CCL3L1 and HIV susceptibility, and ß-defensins and Crohn's disease. Quantification of precise gene copy numbers is important in order to define any association of gene copy number with disease. At present, real-time quantitative PCR (QPCR) is the most commonly used method to determine gene copy number, however the Paralogue Ratio Test (PRT) is being used in more and more laboratories.
- Type:
- Journal article
- Language:
- English
- Published in:
- P L O S One, 2011, Vol 6, Issue 2
- Keywords:
- Base Sequence; Chromosome Mapping; Cohort Studies; Czech Republic; Denmark; Gene Dosage; Genetic Predisposition to Disease; Genetics, Population; Genome, Human; Ghana; Great Britain; Humans; Molecular Sequence Data; Population; Portugal; beta-Defensins
- Main Research Area:
- Medical science
- Publication Status:
- Published
- Review type:
- Peer Review
- Submission year:
- 2011
- Scientific Level:
- Scientific
- ID:
- 180284147
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