Change in brain network connectivity during PACAP38-induced migraine attacks: A resting-state functional MRI study

Faisal Mohammad Amin; Anders Hougaard; Stefano Magon; Mohammad Sohail Asghar; Nur Nabil Ahmad; Egill Rostrup; Till Sprenger; Messoud Ashina

doi:10.1212/WNL.0000000000002261

Change in brain network connectivity during PACAP38-induced migraine attacks

Forfattere:

Amin, Faisal Mohammad ;
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Hougaard, Anders ;
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Magon, Stefano ;
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Asghar, Mohammad Sohail ;
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Ahmad, Nur Nabil ;
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Rostrup, Egill ;
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Sprenger, Till ;
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Ashina, Messoud
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Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet

Undertitel:

A resting-state functional MRI study

DOI:

10.1212/WNL.0000000000002261

Resumé:

OBJECTIVE: To investigate resting-state functional connectivity in the salience network (SN), the sensorimotor network (SMN), and the default mode network (DMN) during migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38 (PACAP38). METHODS: In a double-blind, randomized study, 24 female migraine patients without aura received IV PACAP38 or vasoactive intestinal polypeptide (VIP) over 20 minutes. Both peptides are closely related and cause vasodilation, but only PACAP38 induces migraine attacks. VIP was therefore used as active placebo. Resting-state functional MRI was recorded before and during PACAP38-induced migraine attacks and before and after VIP infusion. We analyzed data by Statistical Parametric Mapping 8 and the Resting-State fMRI Data Analysis Toolkit for Matlab in a seed-based fashion. RESULTS: PACAP38 (n = 16) induced migraine attacks and increased connectivity with the bilateral opercular part of the inferior frontal gyrus in the SN. In SMN, there was increased connectivity with the right premotor cortex and decreased connectivity with the left visual cortex. Several areas showed increased (left primary auditory, secondary somatosensory, premotor, and visual cortices) and decreased (right cerebellum and left frontal lobe) connectivity with DMN. We found no resting-state network changes after VIP (n = 15). CONCLUSIONS: PACAP38-induced migraine attack is associated with altered connectivity of several large-scale functional networks of the brain.

Type:

Tidsskrift-artikel

Sprog:

Engelsk

Udgivet i:

Neurology, 2016, Vol 86, Issue 2, p. 180-7

Emneord:

Adult; Brain; Brain Mapping; Double-Blind Method; Female; Humans; Magnetic Resonance Imaging; Migraine Disorders; Nerve Net; Neurotransmitter Agents; Pituitary Adenylate Cyclase-Activating Polypeptide; Young Adult; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Hovedforskningsområde:

Medical science

Publikationsstatus:

Publiceret

Review type:

Peer Review

Indberetningsår:

2016

Videnskabeligt niveau:

Videnskabelig

ID:

2289831707

Change in brain network connectivity during PACAP38-induced migraine attacks

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