Jensen, Jesper Bo Damm2; Pedersen, Lars H.4; Hoiby, Poul E.4; Nielsen, Lars B.4; Hansen, Theis Peter2; Folkenberg, Jacob Riis5; Riishede, Jesper6; Noordegraaf, Danny2; Nielsen, Kristian7; Carlsen, Anneline7; Bjarklev, Anders Overgaard8
1 Glass Components and Materials, Department of Photonics Engineering, Technical University of Denmark2 Department of Photonics Engineering, Technical University of Denmark3 Fiber Optics, Devices and Non-linear Effects, Department of Photonics Engineering, Technical University of Denmark4 Bioneer A/S5 Crystal Fibre A/S6 Department of Mechanical Engineering, Technical University of Denmark7 unknown8 Rector’s office, Administration, Technical University of Denmark
We demonstrate highly efficient evanescent-wave detection of fluorophore-labeled biomolecules in aqueous solutions positioned in the air holes of the microstructured part of a photonic crystal fiber. The air-suspended silica structures located between three neighboring air holes in the cladding crystal guide light with a large fraction of the optical field penetrating into the sample even at wavelengths in the visible range. An effective interaction length of several centimeters is obtained when a sample volume of less than 1 µL is used.
Optics Letters, 2004, Vol 29, Issue 17, p. 1974-1976