We utilise pulsed AC plasma polymerisation to create thin films that either contain reactive acid functional groups (by deposition of maleic anhydride (MAH) followed by hydrolysis) or are poly(ethylene glycol) (PEG)-like in nature (by using diethylene glycol vinyl ether (DEGVE) as monomer). The MAH films were further modified with PEG chains using a two-step wet chemical method. For the DEGVE films the plasma power was varied in order to change the degree of monomer fragmentation and thus retention of PEG-like character. The chemistry of the surfaces was determined using Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and time-of-flight secondary ion mass spectroscopy (ToF SIMS). Significant reduction (up to 90%) in protein adsorption was achieved.
Plasma Processes and Polymers, 2005, Vol 2, Issue 1, p. 53-63