1 Clinical Microbiology, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU2 Oncology, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU3 Syddansk Universitet4 Clinical Microbiology, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU5 Oncology, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU
A multi-institutional cohort study in denmark
Introduction: Several publications have reported a relation between nosocomial infections and the number of microorganisms in a hospital environment. ATP determinations are listed as a possible method for assessing hospital cleanliness. Objectives: To determine whether ATP determination as a marker of the microbial load can be used to assess level of hospital cleanliness compared to visual inspections and microbiological control. Methods: During one month four hospital rooms in an oncology ward were inspected using 1. Visual inspections according to Danish standards (DS-2451-10 and DS INSTA 800) 2. ATP determinations using 3 M" Clean-Trace" NGi Luminometer 3. Microbiological control using a TSI contact plate. Microbial load was determined by aerobic colony count and expressed as colony forming units per cm2 (CFU/cm2). All microorganisms were identified. The visual control and ATP determinations were made by the same supervisor. The cleaning staff was the same throughout the period. The microbiological control was performed by a microbiologist. Results: There is no consistency between the various techniques. There is a major difference between the two visual methods, and these are not concordant with ATP determinations. In only 70% of cases there is consistency between ATP measurements and microbiological control. Conclusions: ATP determinations cannot currently be recommended for controlling hospital cleanliness, because of the absence of sufficient correlation between this technique and microbiological controls. ATP determination may be useful as a method to identify surfaces which are difficult to clean.
Supportive Care in Cancer, 2015, Vol 23, Issue SUPPL. 1
*hospital *neoplasm pathogen load microorganism microbiology colony forming unit hospital infection photometer oncology ward *adenosine triphosphate marker; *rehabilitation *cancer patient *human *neoplasm rehabilitation center patient heart disease quality of life cardiac patient solid mortality learning hospitalization diagnosis economic aspect cancer survivor; *neoplasm *risk human chemotherapy quality of life cancer survivor prevention single nucleotide polymorphism peripheral neuropathy predictive value side effect genomics glove detoxification genotype gene DNA repair genetic variability patient toxicity platinum derivative enzyme DNA; *hypothyroidism *radiotherapy *neoplasm thyroid gland neck human patient risk factor surgery radiation radiation dose planning model chemotherapy breast cancer subclinical hypothyroidism Hodgkin disease head and neck squamous cell carcinoma data extraction treatment planning thyroid function risk prediction tissues; *osteoporosis *chemotherapy *breast cancer *neoplasm *risk human patient osteolysis hip spine adjuvant chemotherapy secondary osteoporosis radius bone density Fisher exact test cohort analysis drug therapy fracture cancer patient forearm absorptiometry X ray imaging cancer chemotherapy prednisolone corticosteroid marker calcium vitamin D; *overall survival *patient *human *neoplasm *Charlson Comorbidity Index stereotactic body radiation therapy comorbidity lung cancer non small cell lung cancer scoring system medical record review physician survival control group histology gender follow up smoking tumor volume data base; *febrile neutropenia *cancer patient *human *neoplasm male female chemotherapy patient cerebrospinal fluid drug dose reduction risk aged prostate diagnosis Denmark prospective study ovary cancer university hospital oncology retrospective study density prognosis adverse drug reaction *granulocyte colony stimulating factor; *salivary gland function *radiation dose *salivary gland *radiotherapy *head and neck cancer *neoplasm salivation xerostomia stimulus chewing gum radiotherapy planning system side effect flow rate questionnaire prescription drug megadose human patient submandibular gland pilot study food saliva sugar; *head and neck cancer *radiation *neoplasm mucosa inflammation risk proportional hazards model acceleration human regression analysis log rank test patient radiotherapy intensity modulated radiation therapy; 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*rehabilitation *interview *oncology ward *nursing *neoplasm human nurse patient intuition hospitalization oral communication hematology ward skill oncology verbal communication communication skill nursing competence questionnaire interpersonal communication; *hospital infection *neoplasm human patient oncology ward infection ward risk urinary tract diarrhea disease control bacteremia safety health care pneumonia serum hospitalization infection control surgical ward mouth hygiene prevention immune system; *central venous catheter *bloodstream infection *therapy *acute lymphoblastic leukemia *cohort analysis *Denmark *neoplasm human patient risk child attributable risk diagnosis death pediatric hospital confidence interval population high risk population neutropenia Gram positive infection; *side effect *human *retrospective study *neoplasm *eye disease patient eye non small cell lung cancer tear flow blurred vision conjunctivitis Denmark oncology toxicity quality of life university hospital clinical practice dry eye palliative therapy swelling skin *pemetrexed; *myeloma *patient *human *neoplasm survival morbidity death kidney failure diagnosis scoring system quality of life hope disease severity infection; *human *neoplasm *nurse *patient *skill *sexuality *hematology *oncology sexual dysfunction conversation health practitioner prevalence sexual orientation society cancer therapy interview sexual function literature counseling coping behavior