Kamran, Faisal1; Abildgaard, Otto Højager Attermann2; Subash, Arman Ahamed6; Andersen, Peter E.5; Andersson-Engels, Stefan6; Khoptyar, Dmitry6
1 Department of Photonics Engineering, Technical University of Denmark2 Department of Applied Mathematics and Computer Science, Technical University of Denmark3 Diode Lasers and LED Systems, Department of Photonics Engineering, Technical University of Denmark4 Lund University5 Copenhagen Center for Health Technology, Center, Technical University of Denmark6 Lund University
Photon time-of-flight (PTOF) spectroscopy enables the estimation of absorption and reduced scattering coefficients of turbid media by measuring the propagation time of short light pulses through turbid medium. The present investigation provides a comparison of the assessed absorption and reduced scattering coefficients from PTOF measurements of intralipid 20% and India ink-based optical phantoms covering a wide range of optical properties relevant for biological tissues and dairy products. Three different models are used to obtain the optical properties by fitting to measured temporal profiles: the Liemert-Kienle model (LKM), the diffusion model (DM) and a white Monte-Carlo (WMC) simulation-based algorithm. For the infinite space geometry, a very good agreement is found between the LKM and WMC, while the results obtained by the DM differ, indicating that the LKM can provide accurate estimation of the optical parameters beyond the limits of the diffusion approximation in a computational effective and accurate manner. This result increases the potential range of applications for PTOF spectroscopy within industrial and biomedical applications.
Optics Express, 2015, Vol 23, Issue 5, p. 6937-6945