Schwensen, Jakob F2; Lundov, Michael3; Bossi, Rossana10; Banerjee, Piu5; Giménez-Arnau, Elena6; Lepoittevin, Jean-Pierre Lepoittevin6; Lidén, Carola7; Uter, Wolfgang8; Yazar, Kerem Yazar7; White, Ian R.5; Johansen, Jeanne D.9
1 Department of Environmental Science - Environmental chemistry & toxicology, Department of Environmental Science, Science and Technology, Aarhus University2 National Allergy Research Centre, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, 2900, Hellerup, Denmark.3 National Allergy Research Centre, Gentofte Hospital, University of Denmark4 Department of Environmental Science - Atmospheric chemistry and physics (Atmospheric proceses) (ATPRO), Department of Environmental Science, Science and Technology, Aarhus University5 St John’s Institute of Dermatology, St Thomas’ Hospital, London, UK,6 Laboratoire de Dermatochimie, CNRS and University of Strasbourg, France7 Institute of Environmental Medicine, Karolinska Institutet, Stockholm8 Friedrich-Alexander-University of Erlangen-Nuremberg9 Department of Dermato-Allergology, Copenhagen University Hospital Gentofte10 Department of Environmental Science - Atmospheric chemistry and physics (Atmospheric proceses) (ATPRO), Department of Environmental Science, Science and Technology, Aarhus University
a multicentre study of paints from five European countries
BACKGROUND: In view of the current epidemic of contact allergy to methylisothiazolinone (MI), it is important to clarify the extent of use of MI and related isothiazolinones in paints currently available for the consumer and worker in Europe. OBJECTIVES: To elucidate the use and concentrations of MI, methylchloroisothiazolinone (MCI) and benzisothiazolinone (BIT) in paints on the European retail market. METHODS: Wall paints (n = 71) were randomly purchased in retail outlets in five European countries. The paints were quantitatively analysed for their contents of MI, MCI and BIT by high-performance liquid chromatography coupled to tandem mass spectrometry. RESULTS: MI was found in 93.0% (n = 66) of the paints, with concentrations ranging from 0.7 to 180.9 ppm, MCI in 23.9% (n = 17), ranging from 0.26 to 11.4 ppm, and BIT in 95.8% (n = 68), ranging from 0.1 to 462.5 ppm. High concentrations of MI were found in paints from all five countries. Paints purchased in Denmark and Sweden contained especially high concentrations of BIT. CONCLUSION: The use of MI across European countries is extensive. In view of the ongoing epidemic of MI contact allergy, an evaluation of the safety of MI in paints is needed.
Contact Dermatitis, 2015, Vol 72, Issue 3, p. 127-138