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Current state of genome-scale modeling in filamentous fungi

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Authors:
  • Brandl, Julian ;
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    Orcid logo0000-0002-3479-8642
    Network Engineering of Eukaryotic Cell Factories, Department of Systems Biology, Technical University of Denmark
  • Andersen, Mikael Rørdam
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    Orcid logo0000-0003-4794-6808
    Network Engineering of Eukaryotic Cell Factories, Department of Systems Biology, Technical University of Denmark
DOI:
10.1007/s10529-015-1782-8
Abstract:
The group of filamentous fungi contains important species used in industrial biotechnology for acid, antibiotics and enzyme production. Their unique lifestyle turns these organisms into a valuable genetic reservoir of new natural products and biomass degrading enzymes that has not been used to full capacity. One of the major bottlenecks in the development of new strains into viable industrial hosts is the alteration of the metabolism towards optimal production. Genome-scale models promise a reduction in the time needed for metabolic engineering by predicting the most potent targets in silico before testing them in vivo. The increasing availability of high quality models and molecular biological tools for manipulating filamentous fungi renders the model-guided engineering of these fungal factories possible with comprehensive metabolic networks. A typical fungal model contains on average 1138 unique metabolic reactions and 1050 ORFs, making them a vast knowledge-base of fungal metabolism. In the present review we focus on the current state as well as potential future applications of genome-scale models in filamentous fungi.
Type:
Journal article
Language:
English
Published in:
Biotechnology Letters, 2015, Vol 37, Issue 6, p. 1131-1139
Keywords:
Filamentous fungi; Genome-scale models; Metabolic engineering; Metabolism; Systems biology
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2015
Scientific Level:
Scientific
ID:
274160164

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