Genetic variation in alcohol metabolizing enzymes among Inuit and its relation to drinking patterns

Peter Bjerregaard; Stine Schou Mikkelsen; Ulrik Becker; Torben Hansen; Janne S Tolstrup

doi:10.1016/j.drugalcdep.2014.09.774

Genetic variation in alcohol metabolizing enzymes among Inuit and its relation to drinking patterns

Authors:

Bjerregaard, Peter ;
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Health in Greenland, National Institute of Public Health, Faculty of Health Sciences, SDU
Mikkelsen, Stine Schou ;
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Department of Population Health and Morbidity, National Institute of Public Health, Faculty of Health Sciences, SDU
Becker, Ulrik ;
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0000-0002-1678-7771
Department of Population Health and Morbidity, National Institute of Public Health, Faculty of Health Sciences, SDU
Hansen, Torben ;
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University of Copenhagen
Tolstrup, Janne S
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Department of Population Health and Morbidity, National Institute of Public Health, Faculty of Health Sciences, SDU

DOI:

10.1016/j.drugalcdep.2014.09.774

Abstract:

BACKGROUND: Variation in genes involved in alcohol metabolism is associated with drinking patterns worldwide. We compared variation in these genes among the Inuit with published results from the general population of Denmark and, due to the Asian ancestry of the Inuit, with Han Chinese. We analyzed the association between gene variations and drinking patterns among the Inuit. METHODS: We genotyped 4162 Inuit participants from two population health surveys. Information on drinking patterns was available for 3560. Seven single nucleotide polymorphisms (SNPs) were examined: ADH1B arg48his, ADH1C ile350val, ADH1C arg272gln, ALDH2 glu504lys, ALDH2 5'-UTR A-357G, ALDH1B1 ala86val and ALDH1B1 arg107leu. RESULTS: The allele distribution differed significantly between Inuit and the general population of Denmark. A protective effect on heavy drinking was found for the TT genotype of the ALDH1B1 arg107leu SNP (OR=0.59; 95% CI 0.37-0.92), present in 3% of pure Inuit and 37% of Danes. The ADH1C GG genotype was associated with heavy drinking and a positive CAGE test (OR 1.34; 95% CI 1.05-1.72). It was present in 27% of Inuit and 18% of Danes. The Asian genotype pattern with a high frequency of the ADH1B A allele and an ALDH2 gene coding for an inactive enzyme was not present in Greenland. CONCLUSIONS: ADH1C and ALDH1B1 arg107leu SNPs play a role in the shaping of drinking patterns among the Inuit in Greenland. A low frequency of the ALDH1B1 arg107leu TT genotype compared with the general population in Denmark deserves further study. This genotype was protective of heavy drinking among the Inuit.

Type:

Journal article

Language:

English

Published in:

Drug and Alcohol Dependence, 2014, Vol 144, p. 239-244

Keywords:

Journal Article

Main Research Area:

Medical science

Publication Status:

Published

Review type:

Peer Review

Submission year:

2014

Scientific Level:

Scientific

ID:

272463751

Genetic variation in alcohol metabolizing enzymes among Inuit and its relation to drinking patterns

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