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Characterizing the human hematopoietic CDome

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Authors:
  • Barnkob, Mike Stein ;
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    University of Southern Denmark
  • Simon, Christian ;
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    Department of Systems Biology, Technical University of Denmark
  • Olsen, Lars Rønn
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    Department of Bio and Health Informatics, Technical University of Denmark
DOI:
10.3389/fgene.2014.00331
Abstract:
In this study, we performed extensive semi-automated data collection from the primary and secondary literature in an effort to characterize the expression of all membrane proteins within the CD scheme on hematopoietic cells. Utilizing over 6000 data points across 305 CD molecules on 206 cell types, we seek to give a preliminary characterization of the "human hematopoietic CDome." We encountered severe gaps in the knowledge of CD protein expression, mostly resulting from incomplete and unstructured data generation, which we argue inhibit both basic research as well as therapies seeking to target membrane proteins. We detail these shortcomings and propose strategies to overcome these issues. Analyzing the available data, we explore the functional characteristics of the CD molecules both individually and across the groups of hematopoietic cells on which they are expressed. We compare protein and mRNA data for a subset of CD molecules, and explore cell functions in the context of CD protein expression. We find that the presence and function of CD molecules serve as good indicators for the overall function of the cells that express them, suggesting that increasing our knowledge about the cellular CDome may serve to stratify cells on a more functional level.
Type:
Journal article
Language:
English
Published in:
Frontiers in Genetics, 2014, Vol 5, p. 1-10
Keywords:
Proteomics; Immunotherapy; Membraneproteins; CD molecules; Flow cytometry; Immunophenotyping
Main Research Area:
Science/technology
Publication Status:
Published
Review type:
Peer Review
Submission year:
2015
Scientific Level:
Scientific
ID:
272334700

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