Al Olama, Ali Amin2; Kote-Jarai, Zsofia2; Berndt, Sonja I2; Conti, David V2; Schumacher, Fredrick2; Han, Ying2; Benlloch, Sara2; Hazelett, Dennis J2; Wang, Zhaoming2; Saunders, Ed2; Leongamornlert, Daniel2; Lindstrom, Sara2; Jugurnauth-Little, Sara2; Dadaev, Tokhir2; Tymrakiewicz, Malgorzata2; Stram, Daniel O2; Rand, Kristin2; Wan, Peggy2; Stram, Alex2; Sheng, Xin2; Pooler, Loreall C2; Park, Karen2; Xia, Lucy2; Tyrer, Jonathan2; Kolonel, Laurence N2; Le Marchand, Loic2; Hoover, Robert N2; Machiela, Mitchell J2; Yeager, Merideth2; Burdette, Laurie2; Chung, Charles C2; Hutchinson, Amy2; Yu, Kai2; Goh, Chee2; Ahmed, Mahbubl2; Govindasami, Koveela2; Guy, Michelle2; Tammela, Teuvo L J2; Auvinen, Anssi2; Wahlfors, Tiina2; Schleutker, Johanna2; Visakorpi, Tapio2; Leinonen, Katri A2; Xu, Jianfeng2; Aly, Markus2; Donovan, Jenny2; Travis, Ruth C2; Key, Tim J2; Siddiq, Afshan2; Canzian, Federico2; Khaw, Kay-Tee2; Takahashi, Atsushi2; Kubo, Michiaki2; Pharoah, Paul2; Pashayan, Nora2; Weischer, Maren2; Nordestgaard, Borge G2; Nielsen, Sune F2; Klarskov, Peter2; Røder, Martin Andreas3; Iversen, Peter3; Thibodeau, Stephen N2; McDonnell, Shannon K2; Schaid, Daniel J2; Stanford, Janet L2; Kolb, Suzanne2; Holt, Sarah2; Knudsen, Beatrice2; Coll, Antonio Hurtado2; Gapstur, Susan M2; Diver, W Ryan2; Stevens, Victoria L2; Maier, Christiane2; Luedeke, Manuel2; Herkommer, Kathleen2; Rinckleb, Antje E2; Strom, Sara S2; Pettaway, Curtis2; Yeboah, Edward D2; Tettey, Yao2; Biritwum, Richard B2; Adjei, Andrew A2; Tay, Evelyn2; Truelove, Ann2; Niwa, Shelley2; Chokkalingam, Anand P2; Cannon-Albright, Lisa2; Cybulski, Cezary2; Wokołorczyk, Dominika2; Kluźniak, Wojciech2; Park, Jong2; Sellers, Thomas2; Lin, Hui-Yi2; Isaacs, William B2; Partin, Alan W2; Brenner, Hermann2; Dieffenbach, Aida Karina2; Stegmaier, Christa2; Chen, Constance2; Giovannucci, Edward L2; Ma, Jing2; Stampfer, Meir2; Penney, Kathryn L2; Mucci, Lorelei2; John, Esther M2; Ingles, Sue A2; Kittles, Rick A2; Murphy, Adam B2; Pandha, Hardev2; Michael, Agnieszka2; Kierzek, Andrzej M2; Blot, William2; Signorello, Lisa B2; Zheng, Wei2; Albanes, Demetrius2; Virtamo, Jarmo2; Weinstein, Stephanie2; Nemesure, Barbara2; Carpten, John2; Leske, Cristina2; Wu, Suh-Yuh2; Hennis, Anselm2; Kibel, Adam S2; Rybicki, Benjamin A2; Neslund-Dudas, Christine2; Hsing, Ann W2; Chu, Lisa2; Goodman, Phyllis J2; Klein, Eric A2; Zheng, S Lilly2; Batra, Jyotsna2; Clements, Judith2; Spurdle, Amanda2; Teixeira, Manuel R2; Paulo, Paula2; Maia, Sofia2; Slavov, Chavdar2; Kaneva, Radka2; Mitev, Vanio2; Witte, John S2; Casey, Graham2; Gillanders, Elizabeth M2; Seminara, Daniella2; Riboli, Elio2; Hamdy, Freddie C2; Coetzee, Gerhard A2; Li, Qiyuan2; Freedman, Matthew L2; Hunter, David J2; Muir, Kenneth2; Gronberg, Henrik2; Neal, David E2; Southey, Melissa2; Giles, Graham G2; Severi, Gianluca2; Cook, Michael B2; Nakagawa, Hidewaki2; Wiklund, Fredrik2; Kraft, Peter2; Chanock, Stephen J2; Henderson, Brian E2; Easton, Douglas F2; Eeles, Rosalind A2; Haiman, Christopher A2
1 Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet2 unknown3 Department of Clinical Medicine, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Københavns Universitet
Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.
Nature Genetics, 2014, Vol 46, Issue 10, p. 1103-1109
Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Male; Polymorphism, Single Nucleotide; Prostatic Neoplasms; Risk Assessment; Risk Factors