Kjeldsen, Thea S. B.5; Overgaard, Martin6; Nielsen, Søren S.5; Bortolaia, Valeria7; Jelsbak, Lotte5; Sommer, Morten Otto Alexander3; Guardabassi, Luca5; Olsen, John E.5
1 Department of Systems Biology, Technical University of Denmark2 Drug Resistance and Community Dynamics, Department of Systems Biology, Technical University of Denmark3 Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark4 Bacterial Cell Factories, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark5 University of Copenhagen6 Odense University Hospital7 National Food Institute, Technical University of Denmark
blaCTX-M-1 mRNA expression and CTX-M-1 protein levels were dependent on cefotaxime concentration, growth phase and gene location. These results provide insight into the expression of cephalosporin resistance in CTX-M-1-producing E. coli, improving our understanding of the relationship between antimicrobial therapy and the expression of resistance mechanisms.
Journal of Antimicrobial Chemotherapy, 2015, Vol 70, Issue 1, p. 62-70