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Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia

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Authors:
  • Qvist, Tavs ;
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    Københavns Universitet
  • Gilljam, Marita ;
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    University of Gothenburg
  • Jönsson, Bodil ;
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    Clinical Microbiology Laboratories, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Taylor-Robinson, David ;
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    University of Liverpool, Department of Public Health and Policy
  • Jensen-Fangel, Søren ;
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    Department of Clinical Medicine, Health, Aarhus University
  • Wang, Mikala ;
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    Department of Clinical Medicine - Klinisk Mikrobiologi, Department of Clinical Medicine, Health, Aarhus University
  • Svahn, Anita ;
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    Department of Clinical Microbiology, Karolinska University Hospital, Solna, Sweden.
  • Kötz, Karsten ;
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    University of Gothenburg
  • Hansson, Lennart ;
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    Skåne University Hospital, Lund
  • Hollsing, Annika ;
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    Uppsala CF center, KBH, Uppsala University Hospital, Sweden.
  • Hansen, Christine R. ;
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    Department of Pediatrics, Copenhagen University Hospital Rigshospitalet, Denmark.
  • Finstad, Pål L ;
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    Norwegian Resource Centre for Cystic Fibrosis, Oslo University Hospital, Oslo, Norway.
  • Pressler, Tania ;
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    Copenhagen CF Center, Department of Infectious Diseases, University Hospital Rigshospitalet, Denmark.
  • Katzenstein, Terese Lea
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    Department of Infectious Diseases, Copenhagen University Hospital
DOI:
10.1016/j.jcf.2014.08.002
Abstract:
BACKGROUND: Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described. METHODS: In this retrospective observational study we identified all Scandinavian CF patients with a positive NTM culture from airway secretions from 2000 to the end of 2012 and used national CF databases to describe microbiological and clinical characteristics. RESULTS: During the 13-year period 157 (11%) CF patients were culture positive for NTM at least once. Mycobacterium abscessus complex (MABSC) (45%) and Mycobacterium avium complex (MAC) (32%) were the predominant species with geographical differences in distribution. Younger patients were more prone to MABSC (p<0.01). Despite treatment, less than one-third of MABSC patients with repeated positive cultures cleared their infection and a quarter had a lung transplant or died. CONCLUSION: NTM are significant CF pathogens and are becoming more prevalent in Scandinavia. MABSC and MAC appear to target distinct patient groups. Having multiple positive cultures despite treatment conveys a poor outcome.
Type:
Journal article
Language:
English
Published in:
Journal of Cystic Fibrosis, 2015, Vol 14, Issue 1, p. 46-52
Keywords:
Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2015
Scientific Level:
Scientific
ID:
270537059

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