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Cytokine response in peripheral blood indicates different pathophysiological mechanisms behind anastomotic leakage after low anterior resection

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Authors:
  • Pedersen, Mark Ellebæk ;
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    Surgery, Department of Clinical Research, Faculty of Health Sciences, SDU
  • Baatrup, G ;
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    Kirurgisk Afdeling, Institute of Regional Health Research, Faculty of Health Sciences, SDU
  • Gjedsted, J ;
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    unknown
  • Fristrup, C ;
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    Surgery, Department of Clinical Research, Faculty of Health Sciences, SDU
  • Qvist, N
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    Surgery, Department of Clinical Research, Faculty of Health Sciences, SDU
Subtitle:
a pilot study
DOI:
10.1007/s10151-014-1204-2
Abstract:
BACKGROUND: Anastomotic leakage (AL) after rectosigmoid resection is a serious complication associated with high morbidity and mortality. This case-control pilot study investigated the changes in blood concentration of 10 different cytokines and 2 complement factors in relation to symptomatic AL after low anterior resection for rectosigmoid cancer. METHODS: Fifty patients scheduled for resection of rectosigmoid cancer had blood samples taken the day before surgery and on post-operative days 1, 3 and 5. Four patients with symptomatic AL were identified. Twenty-two age- and disease-matched patients constituted the control group. The concentration of 10 cytokines (granulocyte macrophage colony-stimulating factor, interferon-γ, interleukin-1β, interleukin-2, interleukin-4, interleukin-5, interleukin-6, interleukin-8, interleukin-10 and tumour necrosis factor-α) and 2 complement factors (mannan-binding lectin and membrane attack complex) were measured. RESULTS: The present study demonstrated that plasma concentration of interleukin-1β, interleukin-6, interleukin-8 and interleukin 10 within the first 5 post-operative days was increased in patients who developed early clinical AL, whereas there were no changes in patients with late-onset AL. CONCLUSIONS: The demonstrated differences in the cytokine response in early and late AL may support the theory of different pathological mechanisms of AL.
Type:
Journal article
Language:
English
Published in:
Techniques in Coloproctology, 2014, Vol 18, Issue 11, p. 1067-1074
Main Research Area:
Medical science
Publication Status:
Published
Review type:
Peer Review
Submission year:
2014
Scientific Level:
Scientific
ID:
270329497

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