Pedersen, Charlotte5; Thomsen, Camilla F4; Hosbond, Susanne Elisabeth6; Thomassen, Anders7; Mickley, Hans6; Diederichsen, Axel C P6
1 Cardiology, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU2 Clinical Physiology and Nuclear Medicine, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU3 Kemisk Institut, Faculty of Science, SDU4 unknown5 Kemisk Institut, Faculty of Science, SDU6 Cardiology, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU7 Clinical Physiology and Nuclear Medicine, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU
Abstract Objective: To determine the risk of administration of β-blockers, contrast induced nephropathy (CIN) and trend in x-rays use, during coronary computed tomography angiography (CCTA). Methods: A total of 416 patients were referred for elective CCTA. To achieve a resting heart rate below 60 beats per minute oral and / or intravenously β-blockers were administered. Information was collected from patients on the adverse effects of β-blockers in the form of questionnaires. S-creatinine and estimated GFR (eGFR) were measured before and after contrast enhanced CCTA. Radiation exposure was compared with the exposure 3 years before. Results: There was no significant difference in the symptoms (dizziness, lipothymia and palpitations) between patients in and patients without β-blocker pre-treatment. Compared to baseline values, s-creatinine decreased non-significantly (75.2 versus 74.6 µmol/L, p=0.09), while eGFR increased non-significantly (78 versus 79 mL/min, p=0.17). Also subgroups of patients with hypertension, hypercholesterolemia, diabetes or pre-excisting slightly impaired renal function did not develop CIN. Mean radiation exposure decreased from 17.5 to 6.7 mSv, p<0.0001. Conclusions: In terms of side effects to β-blockers and contrast media, there were no short term complications to CCTA. Furthermore the radiation dose was dramatically diminished over the last three years.
Scandinavian Cardiovascular Journal, 2014, Vol 48, Issue 5, p. 271-277