Hamilton, Alexander2; Newby, Paul R3; Carr-Smith, Jacqueline D3; Disanto, Giulio3; Allahabadia, Amit3; Armitage, Mary3; Brix, Thomas H4; Chatterjee, Krishna3; Connell, John M3; Hegedüs, Laszlo4; Hunt, Penny J3; Lazarus, John H3; Pearce, Simon H3; Robinson, Bruce G3; Taylor, Jenny C3; Vaidya, Bijay3; Wass, John A H3; Wiersinga, Wilmar M3; Weetman, Anthony P3; Ramagopalan, Sreeram V3; Franklyn, Jayne A3; Gough, Stephen C L3; Simmonds, Matthew J3
1 Endocrinology, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU2 Oxford Centre for Diabetes, Endocrinology, and Metabolism3 unknown4 Endocrinology, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU
CONTEXT: Viral/bacterial infection is proposed as a trigger for the autoimmune thyroid diseases (AITD): Graves' disease (GD) and Hashimoto's thyroiditis (HT). Previous studies in European Caucasian AITD subjects found higher birth rates in the autumn/winter, suggesting those born in the autumn/winter experience increased viral/bacterial exposure after birth, impacting upon immune system development and predisposing to AITD later in life. OBJECTIVE: Month of birth effects were investigated in three independent European Caucasian AITD datasets. DESIGN: Variation in GD and HT onset was compared across months and seasons, with fluctuations across all 12 months analyzed using a Walter-Elwood test. SETTING: The study was conducted at a research laboratory. PATIENTS: National UK Caucasian AITD Case Control Collection (2746 GD and 502 HT compared with 1 423 716 UK births), National UK Caucasian GD Family Collection (239 GD and 227 unaffected siblings), and OXAGEN AITD Caucasian Family Collection (885 GD, 717 HT, and 794 unaffected siblings of European Caucasian decent). MAIN OUTCOME MEASURES: Case-control and family-based association studies were measured. RESULTS: No consistent month of birth effects were detected in GD females or males across all three collections. In HT females from the OXAGEN AITD Caucasian Family Collection, slightly higher birth rates were detected in autumn (Walter's test statistic = 7.47, P = .024) however, this was not seen in the HT females from the case-control cohort. CONCLUSION: Our results suggest in UK/Northern European Caucasian GD subjects, month of birth does not impact on AITD development. Although some month of birth effects for HT females in one collection cannot be excluded, only further work in larger European Caucasian AITD collections can confirm these effects.
Journal of Clinical Endocrinology and Metabolism, 2014, Vol 99, Issue 8