Sikder, K. U.2; Stone, K. A.2; Kumar, P. B. S.3; Laradji, M.2
1 Department of Physics, Chemistry and Pharmacy, Faculty of Science, SDU2 University of Memphis3 Department of Physics, Chemistry and Pharmacy, Faculty of Science, SDU
We investigate the combined effects of transmembrane proteins and the subjacent cytoskeleton on the dynamics of phase separation in multicomponent lipid bilayers using computer simulations of a particle-based implicit solvent model for lipid membranes with soft-core interactions. We find that microphase separation can be achieved by the protein confinement by the cytoskeleton. Our results have relevance to the finite size of lipid rafts in the plasma membrane of mammalian cells. (C) 2014 AIP Publishing LLC.
Journal of Chemical Physics, 2014, Vol 141, Issue 5