Goharian, T S11; Andersen, Lars Bo11; Franks, P W4; Wareham, N J5; Brage, S6; Veidebaum, T7; Ekelund, U8; Lawlor, D A9; Loos, R J F10; Grøntved, A11
1 Department of Sports Science and Clinical Biomechanics, Det Sundhedsvidenskabelige Fakultet, SDU2 Exercise Epidemiology, Department of Sports Science and Clinical Biomechanics, Det Sundhedsvidenskabelige Fakultet, SDU3 Research in Childhood Health (RICH), Department of Sports Science and Clinical Biomechanics, Det Sundhedsvidenskabelige Fakultet, SDU4 1] Department of Clinical Sciences, Lund University, Malmö, Sweden  Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.5 Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.6 University of Southern Denmark7 Centre of Behavioral and Health Sciences, National Institute for Health Development, Tallinn, Estonia.8 1] Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway  Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.9 MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.10 Mount Sinai School of Medicine11 Department of Sports Science and Clinical Biomechanics, Det Sundhedsvidenskabelige Fakultet, SDU
A Mendelian randomization study employing common genetic variants of fasting glucose
The aim of the study was to determine whether genetically raised fasting glucose (FG) levels are associated with blood pressure (BP) in healthy children and adolescents. We used 11 common genetic variants of FG discovered in genome-wide association studies (GWAS), including the rs560887 single-nucleotide polymorphism (SNP) located in the G6PC2 locus found to be robustly associated with FG in children and adolescents, as an instrument to associate FG with resting BP in 1506 children and adolescents from the European Youth Heart Study (EYHS). Rs560887 was associated with increased FG levels corresponding to an increase of 0.08 mmol l(-1) (P=2.4 × 10(-8)). FG was associated with BP, independent of other important determinants of BP in conventional multivariable analysis (systolic BP z-score: 0.32 s.d. per increase in mmol l(-1) (95% confidence interval (CI) 0.20-0.44, P=1.9 × 10(-7)), diastolic BP z-score: 0.13 s.d. per increase in mmol l(-1) (95% CI 0.04-0.21, P=3.2 × 10(-3)). This association was not supported by the Mendelian randomization approach, neither from instrumenting FG from all 11 variants nor from the rs560887, where non-significant associations of glucose with BP were observed. The results of this study could not support a causal association between FG and BP in healthy children and adolescents; however, it is possible that rs560887 has pleiotropic effects on unknown factors with a BP lowering effect or that these results were due to a lack of statistical power.Journal of Human Hypertension advance online publication, 31 July 2014; doi:10.1038/jhh.2014.63.
Journal of Human Hypertension, 2015, Vol 29, Issue 3