1 Erler Group, BRIC Research Groups, BRIC, Københavns Universitet 2 Erler Group, BRIC, Faculty of Health and Medical Sciences, Københavns Universitet 3 Erler Group, BRIC Research Groups, BRIC, Københavns Universitet 4 Erler Group, BRIC, Faculty of Health and Medical Sciences, Københavns Universitet
connecting fibrosis and solid tumor metastasis
Pathologic organ fibrosis is a condition that can affect all major tissues and is typically ascribed to the excessive accumulation of extracellular matrix components, predominantly collagens. It typically leads to compromise of organ function and subsequent organ failure, and it is estimated that 45% of deaths in the developed world are linked to fibrotic disease. Fibrosis and cancer are known to be inextricably linked; however, we are only just beginning to understand the common and overlapping molecular pathways between the two. Here, we discuss what is known about the intersection of fibrosis and cancer, with a focus on cancer metastasis, and highlight some of the exciting new potential clinical targets that are emerging from analysis of the molecular pathways associated with these two devastating diseases. Clin Cancer Res; 20(14); 3637-43. ©2014 AACR.
Journal review article
Clinical Cancer Research, 2014, Vol 20, Issue 14, p. 3637-43
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