1 Department of Systems Biology, Technical University of Denmark2 Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark3 Cancer Systems Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark4 University College London5 University of Leicester6 University of Manchester7 Birmingham Heartlands Hospital8 Cancer Research UK, London Research Institute9 University of Aberdeen10 Heart Hospital11 Velindre Hospital12 University Hospital Llandough13 University Hospital of South Manchester14 Cancer Research UK Manchester Institute15 Aberdeen Royal Infirmary16 University of Birmingham17 Independent Cancer Patient’s Voice18 University of Leicester19 Aberdeen Royal Infirmary
The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.