1 Klinik for Højt Specialiseret Neurorehabilitering/Traumatisk Hjerneskade, Neurocentret, Rigshospitalet, The Capital Region of Denmark2 Afdeling for Neurorehabilitering HVH, Neurocentret, Rigshospitalet, The Capital Region of Denmark3 Moss Rehabilitation Research Institute, Elkins Park, PA. Electronic address: email@example.com Icahn School of Medicine at Mount Sinai5 Moss Rehabilitation Research Institute, Elkins Park, PA.6 Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: firstname.lastname@example.org.
An Individual Growth Curve Approach
OBJECTIVE: To examine person, injury, and treatment characteristics associated with recovery trajectories of people with severe traumatic brain injury (TBI) during inpatient rehabilitation. DESIGN: Observational prospective longitudinal study. SETTING: Two specialized inpatient TBI rehabilitation units, one in US and one in Denmark (DK). PARTICIPANTS: 206 adults with severe non-penetrating TBI admitted directly to inpatient rehabilitation from acute care; excluded for prior disability and intentional etiology of injury. INTERVENTIONS: Naturally occurring treatments delivered within comprehensive multi-disciplinary teams were recorded daily in 15-minute units provided to patients and family members, separately. MAIN OUTCOME MEASURES: Motor and Cognitive FIM measured on admission, discharge, and every 2 weeks in between, analyzed with Individual Growth Curve methodology. RESULTS: Inpatient recovery was best modeled with linear, cubic, and quadratic components: relatively steep recovery was followed by deceleration of improvement, which attenuated prior to discharge. Slower recovery was associated with older age, longer coma, and interruptions to rehabilitation. Patients admitted at lower functional levels received more treatment and more treatment was associated with slower recovery, presumably because treatment was allocated according to need. Thus, effects of treatment on outcome could not be disentangled from effects of case mix factors. CONCLUSIONS: FIM gain during inpatient recovery from severe TBI is not a linear process. In observational studies, the specific effects of treatment on rehabilitation outcomes are difficult to separate from case mix factors that are associated both with outcome and allocation of treatment.
Archives of Physical Medicine and Rehabilitation, 2014, Vol 95, Issue 11, p. 2103-2110
Journal Article; Observational Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.