Viart, Helene Marie-France1; Larsen, T. S.6; Tassone, Chiara3; Andresen, Thomas Lars3; Clausen, Mads Hartvig1
1 Department of Chemistry, Technical University of Denmark2 Organic Chemistry, Department of Chemistry, Technical University of Denmark3 Department of Micro- and Nanotechnology, Technical University of Denmark4 Colloids and Biological Interfaces, Department of Micro- and Nanotechnology, Technical University of Denmark5 Center for Nanomedicine and Theranostics, Center, Technical University of Denmark6 Technical University of Denmark
A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method.
Chemical Communications, 2014, Vol 50, Issue 58, p. 7800-7802