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1 Administration, Department of Chemistry, Faculty of Science, Københavns Universitet 2 Lund University 3 Linnaeus University 4 Administration, Department of Chemistry, Faculty of Science, Københavns Universitet
Biomolecular motors offer self-propelled, directed transport in designed microscale networks and can potentially replace pump-driven nanofluidics. However, in existing systems, transportation is limited to the two-dimensional plane. Here we demonstrate fully one-dimensional (1D) myosin-driven motion of fluorescent probes (actin filaments) through 80 nm wide, Al2O 3 hollow nanowires of micrometer length. The motor-driven transport is orders of magnitude faster than would be possible by passive diffusion. The system represents a necessary element for advanced devices based on gliding assays, for example, in lab-on-a-chip systems with channel crossings and in pumpless nanosyringes. It may also serve as a scaffold for bottom-up assembly of muscle proteins into ordered contractile units, mimicking the muscle sarcomere. © 2014 American Chemical Society.
Nano Letters, 2014, Vol 14, Issue 6, p. 3041-3046
1D gliding assay; actin; Hollow nanowires; molecular motors; motor proteins; myosin
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