Bichara, David A2; Malchau, Erik2; Sillesen, Nanna H1; Cakmak, Selami2; Nielsen, G Petur2; Muratoglu, Orhun K2
1 Department of Orthopaedic Surgery, Amager and Hvidovre Hospital, The Capital Region of Denmark2 unknown
Recent in vitro findings suggest that UHMWPE wear particles containing vitamin E (VE) may have reduced biologic activity and decreased osteolytic potential. We hypothesized that particles from VE-stabilized, radiation cross-linked UHMWPE would cause less osteolysis in a murine calvarial bone model when compared to virgin gamma irradiated cross-linked UHMWPE. Groups received equal amount of particulate debris overlaying the calvarium for 10 days. Calvarial bone was examined using high resolution micro-CT and histomorphometric analyses. There was a statistically significant difference between virgin (12.2%±8%) and VE-UHMWPE (3%±1.4%) groups in regards to bone resorption (P=0.005) and inflammatory fibrous tissue overlaying the calvaria (0.48 vs. 0.20, P<0.0001). These results suggest that VE-UHMWPE particles have reduced osteolytic potential in vivo when compared to virgin UHMWPE.
Journal of Arthroplasty, 2014, Vol 29, Issue 9 Suppl, p. 232-7