de La Torre, Aurélien2; Lee, Yiu Yiu3; Oger, Camille2; Sangild, Per Torp6; Durand, Thierry2; Lee, Jetty Chung-Yung5; Galano, Jean-Marie2
1 Clinical and Experimental Nutrition, Department of Nutrition, Exercise and Sports, Faculty of Science, Københavns Universitet2 Institut des Biomolécules Max Mousseron (IBMM) UMR CNRS 5247-Universités de Montpellier I et II, ENSCM, Faculté de Pharmacie, 15 Av. Charles Flahault, 34093 Montpellier cedex 05 (France).3 unknown4 Comparative Paediatrics and Nutrition, Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, Københavns Universitet5 School of Biological Sciences, The University of Hong Kong Pokfulam Road, Hong Kong SAR (China)6 Comparative Paediatrics and Nutrition, Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, Københavns Universitet
Biomarkers for <em>in vivo</em> adrenic acid peroxidation
The growing importance of lipidomics, and the interest of non-enzymatic metabolites of polyunsaturated fatty acids (PUFAs) prompted us to initiate the synthesis of novel dihomo-IsoF compounds. Such metabolites of adrenic acid, the main PUFA in white matter, were synthesized using a divergent approach based on an orthoester cyclization. LC-MS/MS investigation on pig brains showed the potential of this novel biomarker for the first time, as a powerful new tool for brain lipid peroxidation assessment.
Angewandte Chemie (international Edition), 2014, Vol 53, Issue 24, p. 6249-6252