1 Clinical Pharmacology and Pharmacy, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU2 Phase IV Unit, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU3 unknown4 Clinical Pharmacology and Pharmacy, Department of Public Health, Det Sundhedsvidenskabelige Fakultet, SDU
BackgroundPrevious studies from North America and Iceland have shown that the youngest children within a grade are up to twice as likely to be diagnosed and treated for attention-deficit/hyperactivity disorder (ADHD) compared with their older classmates. We aimed to investigate whether younger age in class is associated with an increased probability of being prescribed medication for ADHD among school-aged children in Denmark. MethodsWe followed all Danish children between 2000 and 2012 from 1st through 6th grade (7-12years). Among children who started school on their age-assigned grade level, we estimated the prevalence proportion ratio (PPR) of receiving ADHD medication between the youngest children in class (born in October-December) and the oldest in class (born in January-March), specified by grade level, calendar year and gender. As a sensitivity analysis, we added children not on their age-assigned grade level to the main calculations. ResultsWe identified 932,032 eligible children for the main analysis, of whom 17.3% were among the youngest and 26.5% among the oldest in class. In total, 1.2% eligible children filled at least one prescription for ADHD medication in 2000-2012. The average PPR over the study period was 1.08 (95% CI, 1.04-1.12) and remained stable across subgroups and sensitivity analyses. Overall, 40% of children born October-December had entered school a year after their age-assigned grade level. ConclusionsContrary to previous study results, we observed almost no relative age effect on medication use for ADHD among children in Denmark. We postulate that this may be due to the high proportion of relatively young children held back by 1year in the Danish school system and/or a generally low prevalence of ADHD medication use in the country.
Journal of Child Psychology and Psychiatry, 2014, Vol 55, Issue 11, p. 1244-1250
Attention-deficit hyperactivity disorder central stimulants children age factors drug utilization evaluation ATTENTION-DEFICIT/HYPERACTIVITY DISORDER DEFICIT HYPERACTIVITY DISORDER DRUG-USE PERSPECTIVE DIAGNOSIS DENMARK