Ballegaard, Charlotte4; Riis, R G C5; Bliddal, H5; Christensen, R8; Henriksen, M5; Bartels, E M5; Lohmander, Stefan9; Hunter, D J7; Bouert, R5; Boesen, M5
1 Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, Det Sundhedsvidenskabelige Fakultet, SDU2 Department of Sports Science and Clinical Biomechanics, Det Sundhedsvidenskabelige Fakultet, SDU3 Orthopaedics, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU4 Retspatologisk Afdeling5 Copenhagen University Hospital6 Faculty Administration - The Faculty of Engineering, Faculty of Engineering, SDU7 Rheumatology Department, Royal North Shore Hospital and Kolling Institute, University of Sydney, NSW, Australia. Electronic address: firstname.lastname@example.org Faculty Administration - The Faculty of Engineering, Faculty of Engineering, SDU9 Orthopaedics, Department of Clinical Research, Det Sundhedsvidenskabelige Fakultet, SDU
A cross-sectional study
OBJECTIVE: To investigate the association between knee pain and signs of inflammation in the infrapatellar fat pad (IPFP) in obese patients with knee osteoarthritis (KOA). DESIGN: In a cross-sectional setting, 3-T conventional contrast-enhanced (CE) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE)-MRI of KOA were analysed to quantify the extent of inflammation in the IPFP, and correlated (Spearman's rank correlation) to pain and other symptoms assessed via the Knee injury and Osteoarthritis Outcome Score (KOOS) (100 = no pain, 0 = extreme pain). The extent of inflammation in the IPFP was assessed according to the MRI Osteoarthritis Knee Score (MOAKS) using CE-MRI and by DCE-MRI perfusion variables. The perfusion variable, "Inflammation", was chosen as primary perfusion variable in the analysis. Intraclass correlation coefficients for the perfusion variables ranged from 0.81 to 0.99. RESULTS: MRI and clinical data were obtained in 95 patients. The typical patient was a woman (82%) with an average age of 65 years (SD 6.5) and a body mass index (BMI) of 32 kg/m(2) (SD 3.7). The bivariate association between KOOS pain and the DCE-MRI perfusion variable "Inflammation" showed a statistically significant correlation (r = -0.42, P < 0.0001). A statistically significant correlation was also found between KOOS pain and MOAKS Hoffa-synovitis (r = -0.21, P = 0.046). CONCLUSIONS: Perfusion variables on DCE-MRI reflecting the severity of inflammation in the IPFP and MOAKS Hoffa-synovitis were associated with the severity of pain in KOA. These results suggest that severe inflammation in the IPFP is associated with severe pain in KOA and that DCE-MRI is a promising method to study the impact of inflammation in KOA.
Osteoarthritis and Cartilage, 2014, Vol 22, Issue 7, p. 933-40
Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't