Nielsen, Dennis Sandris4; Krych, Lukasz4; Buschard, Karsten3; Hansen, Camilla Hartmann Friis5; Hansen, Axel Jacob Kornerup5
1 Microbiology and Fermentation, Department of Food Science, Faculty of Science, Københavns Universitet2 Experimental Animal Models, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, Københavns Universitet3 Bartholin Institute, Rigshospitalet4 Microbiology and Fermentation, Department of Food Science, Faculty of Science, Københavns Universitet5 Experimental Animal Models, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, Københavns Universitet
Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals.
Febs Letters, 2014, Vol 588, Issue 22, p. 4234-4243